Without Escape by PacoChan is a point & click adventure inspired in Resident Evil and Silent Hill, although there are no monsters. The main objective is to escape from your house since it's happening a lot of weird things. Read more about Without Escape v1.4 (NDS Game)
DS2x86 by Patrick Aalto is a PC emulator for Nintendo DS. It's purpose is to allow you to run old DOS games on your Nintendo DS game console. DS2x86 is a port of DSx86 port using the SuperCard DSTwo's MIPS processor, therefor it will just run with such a card. Read more about DS2x86 v0.24 (DOS emu for NDS)
Diablo2 Sorceress Project is a recently resurrected DS homebrew made by LeRodeur. The game is a Diablo 2 tribute, where you play as a sorceress that must survive an onslaught of zombies. see the change log for what's new, and be sure to join the on-going discussion so you can give the author some feedback and ideas for what you'd like to see added to this work-in-progress game. [Text shameless stolen from GBAtemp] Read more about Diablo 2 Sorceress Project v1.0.5 (Alpha) (NDS Game)
Pocket Island DS by MJaoune is an unofficial remake of "Pocket God". There are little guys which you can annoy with your stylus and there are few options to change the weather. It's not yet a game, but the coder plans to add missions. Read more about Pocket Island DS v0.95 (NDS misc)